U.S. 90 is a major west-east highway from Van Horn, TX to Jacksonville Beach, FL. The road is partly featured in the Texas DLC for American Truck Simulator. Beginning in Van Horn at an intersection with I-10, the road heads south-southeast through the Texas desert. Passing Valentine, the road gradually takes on a more easterly direction as it heads towards Marfa.
Continuing east past Marfa, through Marathon, U.S. 90 meets the southern terminus of U.S. 285 in Sanderson. From Sanderson, the highway roughly parallels the U.S.-Mexico border along the Rio Grande, travelling through Dryden, and crossing the Amistad Reservoir into Del Rio. Here, the road turns sharply east towards San Antonio.
Travelling east, U.S. 90 passes through Uvalde before becoming a four lane highway as it heads into San Antonio. In San Antonio, U.S. 90 multiplexes with I-10 into Louisiana, except in some areas around Houston and Beaumont. It's current eastern terminus in-game is just before the Louisiana state line.