- For other European roads numbered M6, see M6 (disambiguation).
The Route Métropolitaine M6 is originally the southernmost section of the .
The designation did not exist when Euro Truck Simulator 2 was released in 2012, and the game's rendering of the ran straight into the center of Lyon.
When SCS Software revamped the game map around Lyon in version 1.43 update, three suburb districts were set up to replace the originally accessible Lyon city center. Two of the districts – Dardilly and Limonest, straddle the on either side. True to changes in real-life, the road south of the suburbs' entrance is signed as the M6.
The road's southern end at Lyon was also changed to connect directly onto its counterpart on (i.e. M7) towards Marseille. However, only the M6 is signed, and the junction layout in Lyon city center remains incorrect, albeit in a different way from the previous rendering.