The main roads depicted in Holbrook are Navajo Boulevard and West Hopi Drive, both of which are part of historic Route 66. Navajo Boulevard features a generic depiction of Holbrook Cemetery just south of the Interstate 40 exit. Other landmarks include the Pow Wow Trading Post and Winners Circle Bar. The road also features two rock shops that in real life sell petrified wood.
West Hopi Drive, which parallels the train tracks, features the Wigwam Motel. Where Hopi Drive and Navajo Boulevard meet are the crossroads of Route 66 plaza.
To the northeast of the city, off of Interstate 40, truckers can also find the entrance to Petrified Forest National Park.
Holbrook is connected to other cities by four roads:
- The connects the city with Flagstaff to the west, concurrent with US 180, and Gallup and Albuquerque, New Mexico to the east.
- The runs to Flagstaff to the west, concurrent with I-40, and St. Johns to the east (inaccessible).
- The intersects I-40 in Sanders east of Holbrook and runs towards St. Johns and Clifton to the south and Mexican Water, Kayenta (the latter city via the ), and Moab, Utah to the north.
- The runs from I-40 and US 180 to Show Low to the south.
|Cities||Camp Verde - Clifton - Ehrenberg - Flagstaff - Grand Canyon Village - Holbrook - Kayenta - Kingman - Nogales - Page - Phoenix - San Simon - Show Low - Sierra Vista - Tucson - Yuma
Scenery Towns: Ash Fork - Bitter Springs - Cameron - Colorado City - Dateland - Fredonia - Globe - Mexican Water - Morenci - Pinetop–Lakeside - Quartzsite - Sanders - Seligman - Springerville - St. Johns - Teec Nos Pos - Valle - Wickenburg
|Highways||Interstate 8 - Interstate 10 - Interstate 15 - Interstate 17 - Interstate 19 - Interstate 40|
US 60 - US 64 - US 70 - US 89 - US 89A - US 93 - US 95 - US 160 - US 163 - US 180 - US 191
SR 51 - SR 61 - SR 64 - SR 66 - SR 77 - SR 85 - SR 89 - SR 90 - SR 92 - SR 98 - SR 260 - SR 303 - SR 389