- The and run to Douglas and Cheyenne to the southeast and Buffalo to the north, and US 87 also runs to Sheridan to the north.
- The and run to Shoshoni to the northwest and Douglas to the east, concurrent with I-25 and US 87, and US 26 also runs to Riverton to the west.
- The runs towards Muddy Gap Junction and Rawlins (the latter city via the and ) to the southwest.
- The runs from WYO 220 south of Casper towards Medicine Bow and Laramie (the latter city via the and ) to the southeast.
SCS Blog (pre-release)
|Cities||Casper - Cheyenne - Evanston - Gillette - Jackson - Laramie - Rawlins - Riverton - Rock Springs - Sheridan
Scenery Towns: Alcova - Alpine - Alpine Junction - Baggs - Bill - Boulder - Buffalo - Buford - Burgess Junction - Creston Junction - Daniel Junction - Devils Tower - Douglas - Dwyer Junction - Evansville - Farson - Green River - Greybull - Hiland - Hoback Junction - Kaycee - Kemmerer - Lander - Little America - Medicine Bow - Moneta - Moorcroft - Moran Junction - Muddy Gap Junction - Orin - Pinedale - Powder River - Reliance - Rock River - Shoshoni - Sweetwater Station - Thermopolis - Wheatland - Wright
|Highways||Interstate 25 - Interstate 80 - Interstate 90 - Interstate 180|
US 14 - US 16 - US 18 - US 20 - US 26 - US 30 - US 85 - US 87 - US 89 - US 189 - US 191 - US 287
WYO 22 - WYO 28 - WYO 50 - WYO 51 - WYO 59 - WYO 76 - WYO 89 - WYO 94 - WYO 110 - WYO 135 - WYO 150 - WYO 210 - WYO 212 - WYO 220 - WYO 222 - WYO 258 - WYO 339 - WYO 351 - WYO 450 - WYO 487 - WYO 789